Iovance Biotherapeutics, Inc. (IOVA) Stock Analysis
Healthcare · Biotechnology · NasdaqGM
Iovance Biotherapeutics, Inc. (IOVA) posted $263.50M in revenue for fiscal 2025 (up 60.6% year over year), with a net loss of $390.98M, per its SEC filings.
Data last refreshed August 2, 2026 from SEC filings · how we compute this
The analyst's take on Iovance Biotherapeutics, Inc.
Iovance Biotherapeutics, Inc. has grown revenue from $0 to $263.50M over the last 10 fiscal years. The most recent year was up 60.6%.
Net margin sits at -148.4%, up 78.4 points year over year on a 34.3% gross margin. It carries about $1.00M of total debt.
The one thing worth a second look in the filings is share count rising (dilution).
Synthesised from Iovance Biotherapeutics, Inc.'s SEC filings — descriptive, not advice. Ask the analyst your own question →
Iovance Biotherapeutics, Inc. revenue & earnings — last 10 fiscal years
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $1.19M | $164.07M | $263.50M |
| Gross profit | — | — | — | — | — | — | — | $156,000 | $70.82M | $90.32M |
| Net income | $-52.89M | $-92.06M | $-123.58M | $-197.56M | $-259.58M | $-342.25M | $-395.89M | $-444.04M | $-372.18M | $-390.98M |
| Net margin | — | — | — | — | — | — | — | -37345.4% | -226.8% | -148.4% |
Source: Iovance Biotherapeutics, Inc. SEC filings (10-K). 18 years of history available in the interactive view.
Iovance Biotherapeutics, Inc.: 3 potential red flags in the filings
Patterns in the filed statements worth a second look — computed and cited, not AI guesswork, and not a signal to sell. The kind of thing that hides in a 10-K.
- Share count rising (dilution)Shares outstanding grew 162.4% over 4 years (157M → 411.9M) — existing holders' stakes are being diluted.
- Debt with negative operating cash flowCarries $2M of debt while last year's operating cash flow was negative ($-302.4M).
- Currently unprofitableThe latest fiscal year was a net loss (net margin -148.4%).
Explore 18 years of Iovance Biotherapeutics, Inc. financials — interactive
Full income statement, balance sheet and cash flow with CAGR and trend on every row, 48 quarters, valuation ratios, plain-English health checks, and Ask — our SEC-grounded research assistant.
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Iovance Biotherapeutics, Inc. financial history by metric
About Iovance Biotherapeutics, Inc.
Iovance Biotherapeutics, Inc., a commercial-stage biopharmaceutical company, develops and commercializes cell therapies using autologous tumor infiltrating lymphocyte for the treatment of metastatic melanoma and other solid tumor cancers in the United States and internationally. The company offers Amtagvi, an individualized T cell therapy for solid tumor cancer and for the treatment of adult patients with previously treated advanced, or unresectable or metastatic melanomal; and Proleukin, an interleukin-2 product for the treatment of patients with metastatic melanoma and metastatic renal cell carcinoma. It also develops lifileucel for the treatment of melanoma, cervical cancer, non-small cell lung cancer (NSCLC), endometrial cancer, and head and neck squamous cell carcinoma (HNSCC); LN-145-S1 to treat melanoma and HNSCC; LN-145 Gen 3 and core biopsy for the treatment of NSCLC; LN-145 Gen 3 to treat melanoma and HNSCC; IOV-2001 to treat chronic lymphocytic leukemia and small lymphocytic lymphoma; IOV-4001 for the treatment of melanoma and NSCLC; and IOV-3001 for use in the TIL therapy treatment regimen. The company has collaborations and licensing agreements with National Institutes of Health; the National Cancer Institute; Cellectis S.A.; Novartis Pharma AG; and Boehringer Ingelheim Biopharmaceuticals GmbH. The company was formerly known as Lion Biotechnologies, Inc. and changed its name to Iovance Biotherapeutics, Inc. in June 2017. Iovance Biotherapeutics, Inc. was incorporated in 2007 and is headquartered in San Carlos, California.
Iovance Biotherapeutics, Inc. — frequently asked questions
What is Iovance Biotherapeutics, Inc.'s revenue?
Iovance Biotherapeutics, Inc. (IOVA) reported revenue of $263.50M for fiscal year 2025, up 60.6% from the prior year, according to its SEC filings.
Is Iovance Biotherapeutics, Inc. profitable?
No — IOVA reported a net loss of $-390.98M in fiscal 2025.
What is IOVA's P/E ratio?
Iovance Biotherapeutics, Inc. trades at a price-to-earnings ratio of about 0.0 based on the latest data in our nightly-refreshed cache.
How much debt does Iovance Biotherapeutics, Inc. have?
As of fiscal year 2025, IOVA carried roughly $1.00M in total debt (short- plus long-term borrowings), per its filed balance sheet.
What is Iovance Biotherapeutics, Inc.'s gross margin?
IOVA's gross margin was 34.3% in fiscal 2025 — gross profit of $90.32M on revenue of $263.50M.
What is Iovance Biotherapeutics, Inc.'s market cap?
Iovance Biotherapeutics, Inc. (IOVA) has a market capitalization of about $1.73B, based on the latest data in our nightly-refreshed cache.
When does Iovance Biotherapeutics, Inc.'s fiscal year end?
IOVA's fiscal year ends in December. Its most recent annual filing covers the fiscal year ending 2025-12-31.
Where does this data come from?
All figures are computed from Iovance Biotherapeutics, Inc.'s official SEC filings (10-K and 10-Q), covering 18 years of history, refreshed nightly. stockportfolio.pro does not provide investment advice.