Crinetics Pharmaceuticals, Inc. (CRNX) Stock Analysis
Healthcare · Biotechnology · NasdaqGS
Crinetics Pharmaceuticals, Inc. (CRNX) posted $7.70M in revenue for fiscal 2025 (up 640.7% year over year), with a net loss of $465.32M, and has compounded revenue about 155.3%/yr over five years, per its SEC filings.
Data last refreshed August 2, 2026 from SEC filings · how we compute this
The analyst's take on Crinetics Pharmaceuticals, Inc.
Crinetics Pharmaceuticals, Inc. has grown revenue from $589,000 to $7.70M over the last 10 fiscal years, compounding about 155.3% a year. The most recent year was up 640.7%, so growth is actually accelerating.
Net margin sits at -6046.2%, up 22674.5 points year over year on a 86% gross margin.
The one thing worth a second look in the filings is share count rising (dilution).
Synthesised from Crinetics Pharmaceuticals, Inc.'s SEC filings — descriptive, not advice. Ask the analyst your own question →
Crinetics Pharmaceuticals, Inc. revenue & earnings — last 10 fiscal years
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $589,000 | $2.04M | $2.43M | $1.19M | $71,000 | $1.08M | $4.74M | $4.01M | $1.04M | $7.70M |
| Gross profit | — | — | — | — | — | — | — | $4.01M | $1.04M | $6.62M |
| Net income | $-6.02M | $-9.16M | $-27.11M | $-50.42M | $-73.81M | $-107.64M | $-163.92M | $-214.53M | $-298.41M | $-465.32M |
| Net margin | -1021.9% | -447.8% | -1116.8% | -4226.5% | -103960.6% | -9985.3% | -3460.4% | -5345.9% | -28720.7% | -6046.2% |
Source: Crinetics Pharmaceuticals, Inc. SEC filings (10-K).
Crinetics Pharmaceuticals, Inc.: 2 potential red flags in the filings
Patterns in the filed statements worth a second look — computed and cited, not AI guesswork, and not a signal to sell. The kind of thing that hides in a 10-K.
- Share count rising (dilution)Shares outstanding grew 100.8% over 4 years (47.6M → 95.6M) — existing holders' stakes are being diluted.
- Currently unprofitableThe latest fiscal year was a net loss (net margin -6046.2%).
Explore 10 years of Crinetics Pharmaceuticals, Inc. financials — interactive
Full income statement, balance sheet and cash flow with CAGR and trend on every row, 48 quarters, valuation ratios, plain-English health checks, and Ask — our SEC-grounded research assistant.
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Crinetics Pharmaceuticals, Inc. financial history by metric
About Crinetics Pharmaceuticals, Inc.
Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company's lead product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in a Phase 3 clinical trial for the treatment of acromegaly and carcinoid syndrome associated with neuroendocrine tumors. It is also developing Atumelnant, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and cushing's disease; and CRN09682, a nonpeptide drug conjugate for SST2 positive solid tumors. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; thyroid-stimulating hormone receptor antagonists for the treatment of graves' disease and thyroid eye disease; and SST3 Agonist program for the treatment of polycystic kidney disease, as well as Oral GLP-1 and Oral GIP nonpeptides for the treatment of obesity. The company has an agreement with Sanwa Kagaku Kenkyusho Co., Ltd to develop and commercialize Paltusotine in Japan, and Cellular Longevity, Inc. to develop and commercialize CRN01941, a somatostatin receptor type 2 agonist. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.
Crinetics Pharmaceuticals, Inc. — frequently asked questions
What is Crinetics Pharmaceuticals, Inc.'s revenue?
Crinetics Pharmaceuticals, Inc. (CRNX) reported revenue of $7.70M for fiscal year 2025, up 640.7% from the prior year, according to its SEC filings.
Is Crinetics Pharmaceuticals, Inc. profitable?
No — CRNX reported a net loss of $-465.32M in fiscal 2025.
What is CRNX's P/E ratio?
Crinetics Pharmaceuticals, Inc. trades at a price-to-earnings ratio of about 0.0 based on the latest data in our nightly-refreshed cache.
How fast is Crinetics Pharmaceuticals, Inc. growing?
CRNX's revenue grew at roughly 155.3% per year over the last five fiscal years (compound annual growth rate), computed from SEC-filed statements.
How much debt does Crinetics Pharmaceuticals, Inc. have?
As of fiscal year 2025, CRNX carried roughly $0 in total debt (short- plus long-term borrowings), per its filed balance sheet.
What is Crinetics Pharmaceuticals, Inc.'s gross margin?
CRNX's gross margin was 86.0% in fiscal 2025 — gross profit of $6.62M on revenue of $7.70M.
What is Crinetics Pharmaceuticals, Inc.'s market cap?
Crinetics Pharmaceuticals, Inc. (CRNX) has a market capitalization of about $3.52B, based on the latest data in our nightly-refreshed cache.
When does Crinetics Pharmaceuticals, Inc.'s fiscal year end?
CRNX's fiscal year ends in December. Its most recent annual filing covers the fiscal year ending 2025-12-31.
Where does this data come from?
All figures are computed from Crinetics Pharmaceuticals, Inc.'s official SEC filings (10-K and 10-Q), covering 10 years of history, refreshed nightly. stockportfolio.pro does not provide investment advice.